Description

Pulmonary Embolism (PE) is a serious medical condition that occurs when a blood clot blocks one of the blood vessels, called pulmonary arteries, that carry blood from the heart to the lungs. In most cases, the clot develops in a deep vein in the leg or pelvis and then travels through the bloodstream to the lungs. This type of blood clot is known as a deep vein thrombosis (DVT).

A pulmonary embolism can be small or large. A small clot may cause mild symptoms, while a large clot can significantly reduce blood flow through the lungs and place severe stress on the heart. In serious cases, pulmonary embolism can become life-threatening and requires immediate medical treatment.

PE is part of a condition known as venous thromboembolism (VTE), which includes both DVT and pulmonary embolism. Understanding the connection between DVT and PE is important because recognizing a blood clot early may help prevent it from traveling to the lungs.

Common symptoms of pulmonary embolism include sudden shortness of breath, chest pain, rapid heartbeat, coughing, and unexplained anxiety or restlessness. Some people may cough up blood. Symptoms can develop suddenly or become noticeable over several hours.

The risk of pulmonary embolism increases when blood flow becomes slow or stagnant, the blood becomes more likely to clot, or the blood vessels are injured. Long periods of immobility, major surgery, serious injuries, certain cancers, pregnancy, and some hormone-based medicines can increase the risk.

Doctors diagnose PE using a combination of medical history, physical examination, blood tests, and imaging. A D-dimer blood test may help determine whether further testing is needed in people with a low or moderate risk. A CT pulmonary angiogram (CTPA) is commonly used to look for a clot in the pulmonary arteries.

Treatment usually involves anticoagulant medicines, commonly called blood thinners. These medicines prevent existing clots from growing and reduce the chance of new clots forming. In severe cases, clot-dissolving medicines or procedures to remove the clot may be necessary.

Because pulmonary embolism can become dangerous quickly, sudden unexplained breathing difficulty or chest pain should never be ignored.

Causes

The most common cause of pulmonary embolism is a blood clot that forms in a deep vein, usually in the leg. This condition is called deep vein thrombosis.

When part of a DVT breaks away, it can travel through the veins toward the heart. From the heart, the clot enters the pulmonary arteries and may become lodged in one of the blood vessels supplying the lungs.

Blood clots are more likely to develop when blood flow slows down, the blood has an increased tendency to clot, or the walls of blood vessels become damaged.

Long periods of immobility are an important risk factor. Sitting for many hours during long-distance travel, staying in bed because of illness, or having limited movement after surgery can slow blood flow in the legs.

Major surgery can increase the risk because of reduced mobility, inflammation, and changes in the body's clotting system.

Serious injuries, especially fractures or trauma involving the legs, pelvis, or abdomen, can also increase the risk.

Certain cancers and cancer treatments can make the blood more likely to clot.

Pregnancy increases the risk of blood clots because of natural changes in the body's clotting system and pressure on veins from the growing uterus. The risk can remain elevated for some time after childbirth.

Some hormone-based medicines, including certain estrogen-containing contraceptives and hormone replacement therapies, can increase the risk of blood clots in susceptible individuals.

A previous history of DVT or pulmonary embolism significantly increases the chance of developing another clot.

Family history and inherited clotting disorders can also increase the risk.

Older age may increase the likelihood of PE, particularly when combined with other risk factors.

Obesity, smoking, and certain chronic medical conditions may contribute to overall blood clot risk.

Some people develop a pulmonary embolism without an obvious trigger. This is sometimes described as an unprovoked pulmonary embolism.

Having one or more risk factors does not mean a person will definitely develop PE. However, understanding these factors can help people and healthcare professionals recognize risk and take appropriate preventive measures.

Symptoms

Pulmonary embolism symptoms can vary depending on the size of the clot, the location of the blockage, and the person's overall health. Symptoms often appear suddenly, although they can sometimes develop gradually.

Sudden shortness of breath is one of the most common symptoms. A person may feel unable to take a full breath or may become breathless without significant physical activity.

Chest pain is another important symptom. The pain may feel sharp or stabbing and can become worse when taking a deep breath or coughing. Some people may experience pressure or discomfort in the chest instead.

A rapid or irregular heartbeat may occur as the heart works harder to maintain blood flow.

Coughing can occur, and some people may cough up blood. Coughing up blood with sudden breathing difficulty requires urgent medical assessment.

Some people experience dizziness, lightheadedness, weakness, or fainting. These symptoms may occur when a large clot significantly interferes with blood flow through the lungs.

An unexplained feeling of anxiety, fear, or restlessness may accompany the physical symptoms.

Sweating and pale or clammy skin may occur, particularly when the embolism is severe.

A pulmonary embolism caused by a DVT may also be associated with symptoms in the leg. These can include swelling, pain, tenderness, warmth, or redness, usually affecting one leg rather than both.

Some people with PE have no obvious leg symptoms because the original clot may be small or may have already traveled to the lungs.

Severe pulmonary embolism can cause very low blood pressure, confusion, loss of consciousness, or signs of shock. This is a medical emergency.

Symptoms can sometimes resemble other conditions such as pneumonia, asthma, heart problems, or a severe respiratory infection. This is why proper medical evaluation is essential.

Anyone experiencing sudden shortness of breath, unexplained chest pain, coughing up blood, fainting, or severe weakness should seek emergency medical care rather than waiting for symptoms to disappear.

Prevention

Pulmonary embolism cannot always be prevented, but reducing the risk of blood clots can significantly lower the chance of developing PE.

Staying physically active is one of the simplest ways to support healthy blood circulation. Regular walking and movement can be especially important for people who spend long periods sitting.

During long-distance travel, try to stand up and walk around regularly when possible. Moving the ankles and legs while sitting can also help maintain circulation.

People who are recovering from surgery or illness should follow their healthcare team's instructions about safe movement. Getting out of bed and walking when medically appropriate can help reduce the risk of blood clots.

Doctors may prescribe preventive anticoagulants for people at high risk after certain surgeries or during particular medical conditions.

Compression stockings may be recommended for selected patients, particularly in certain situations involving reduced mobility or previous venous problems.

Maintaining a healthy weight can help reduce several risk factors associated with blood clots.

Avoiding smoking is beneficial for cardiovascular and blood vessel health.

People taking hormone-based medicines should discuss their individual risk of blood clots with a healthcare professional, particularly if they have a personal or family history of DVT or PE.

Anyone who has previously experienced pulmonary embolism should follow their treatment plan carefully. Stopping anticoagulants without medical advice can increase the risk of another clot.

People with inherited or acquired clotting disorders may require additional preventive strategies.

During hospitalization, healthcare professionals assess clot risk and may use medications, compression devices, or early movement when appropriate.

Recognizing DVT symptoms can also help prevent complications. One-sided leg swelling, unexplained leg pain, warmth, or redness should be medically evaluated, especially in someone with known risk factors.

Emergency symptoms such as sudden shortness of breath, chest pain, coughing up blood, rapid heartbeat, severe dizziness, or fainting require immediate medical attention.

Pulmonary embolism is a serious but treatable condition. Early diagnosis, appropriate anticoagulant treatment, prevention of unnecessary immobility, and awareness of blood clot risk factors can greatly improve outcomes and reduce the chance of dangerous complications.

Medical Information Trust
Evidence-Based Information
Last Updated: October 28, 2026
YMYL Compliant

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider. In an emergency, call emergency services immediately.